Prof. dr. Paul Legrand studied medicine at the KU Leuven and graduated as medical doctor in 1982. Afterwards he studied dentistry and graduated in 1984. He was trained as an oral- and maxillofacial surgeon at the KU Leuven and at the Rheinisch-Westfälische Technische Hochschule in Aachen. In 1988 he became a certified oral and maxillofacial surgeon. In oktober 1988, he founded the oral and maxillofacial surgery department in the Maria Hospital in Overpelt, where he was medical head of OMFS from 1988 to 2017. He is a certified OMFS instructor and a member of the OMFS accreditation committee. Furthermore, he is on the board of the association of Flemish oral and maxillofacial surgeons (VVMKA) and the VBS MKA.

Since 2011 professor Legrand was parttime affiliated with the UZ Leuven and in 2016 he was appointed guest lecturer at the KU Leuven.  Since November 2018, professor Legrand is fulltime staff member at OMFS UZ Leuven.

In Belgium, professor Legrand is a pioneer in intravenous sedation in the OMFS department and he has made this is most important area of interest. His principal activities are dentoalveolar surgery, implantology and further development of intravenous sedation techniques.